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3 M sodium acetate pH 5.2

Ethanol precipitation of DNA and RNA. Titrate with glacial acetic acid.

Component100 mL500 mL1 L
Sodium acetate · 3H₂O40.82 g204.1 g408.2 g
Glacial acetic acidapproximate; finish with a pH meter4.593 mL22.96 mL45.93 mL
Final volume with water100 mL500 mL1 L
  1. Dissolve Sodium acetate · 3H₂O in about 80 % of the final volume of purified water.
  2. Adjust to pH 5.2 at 25 °C with Glacial acetic acid, adding slowly while stirring.
  3. Make up to the final volume with water.
  4. Autoclave or filter-sterilise and store at room temperature.